Tuesday, September 16th, CNS 333 at 4:15 p.m. Alumnus Jason Diaz will be giving a presentation on:
"Phosphorylation as a key regulator of Merkel cell polyomavirus protein function."
Merkel cell polyomavirus (MCV) was discovered in 2008 as a novel DNA virus associated with a very rare skin cancer, Merkel cell carcinoma. Research efforts have focused on how this virus causes cancer, but much of its basic virology has yet to be explored. The major viral protein, Large Tumor antigen (LT) is a multifunction protein that interacts with numerous cellular proteins to manipulate the cell for the virus’s advantage; additionally, LT is a key initiator of viral DNA replication. These multiple activities must be tightly regulated to ensure a productive infectious cycle. Using mass spectrometry, I uncovered three novel threonines that are phosphorylated during LT expression in cells; this talk will demonstrate how some of these modifications control LT’s ability to initiate viral replication.
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https://www.ithaca.edu/intercom/article.php/20140915101132650