Please join us on Thursday, April 2nd at 4:15 p.m. in the Center for Natural Sciences room 333. Please join us on Thursday, April 2nd at 4:15 p.m. in the Center for Natural Sciences room 333.
The presentation will focus on: Glutamine and glucose are versatile sources of energy for rapidly dividing cells and essential for cellular proliferation, growth and survival. The malignant cells transport glutamine and glucose across cell membranes at a faster rate than their normal counterparts. On combining this fundamental biochemical process and function of iron-based MRI PARACEST (paramagnetic chemical exchange saturation transfer) agents would play an important role in early stage detection of cancer cells. We are focusing to exploit the amino acid and glucose transporting system to deliver larger amounts of iron (II) PARACEST agents to the targeted tumour cells. My present talk will be on fundamentals of CEST MRI agents and synthesis of iron (II) complexes of macrocyclic ligands with amide and hydroxyl (-OH) groups as PARACEST agents and their CEST studies. Further, tailoring of amino acid and glucose residues peripheral groups on the ligands to promote cellular uptake also discussed.
All are invited to attend individuals with disabilities requiring accommodations should contact Maria Russell at mrussell@ithaca.edu or (607) 274-3238. We ask that requests for accommodations be made as soon as possible.
https://www.ithaca.edu/intercom/article.php/20150327124255955