James L. Hougland of Syracuse University will present “Greasing the Wheels of Protein Function: The Chemistry and Biology of Protein Lipidation” Tuesday, September 13th @ 12:10 pm in CNS 333, Refreshments providedJames L. Hougland of Syracuse University will present “Greasing the Wheels of Protein Function: The Chemistry and Biology of Protein Lipidation” Tuesday, September 13th @ 12:10 pm in CNS 333, Refreshments provided
Post-translational modifications play an essential role in regulating protein structure, function, and cellular localization. For example, many proteins undergo lipidation modifications that enhance membrane affinity and modulate protein-protein interactions. Enzymes that catalyze these modifications must often selectively recognize and modify multiple substrate proteins from among a plethora of non-substrates with similar structures and amino acid sequences, thereby overcoming a significant challenge of molecular recognition. In many aspects, protein lipidation presents an ideal system for investigating how a small number of chemical modifications can control complex biological pathways. Individuals with disabilities requiring accommodations should contact Akiko Fillinger at afillinger@ithaca.edu or Paula Larsen at plarsen@ithaca.edu or (607) 274-3238 .We ask that requests for accommodations be made as soon as possible.
https://www.ithaca.edu/intercom/article.php/20160909121749167