Dr. Hening Lin of Chemistry and Chemical Biology Department, Cornell University will present Sirtuins and novel protein modifications in cell signaling and cancer Dr. Hening Lin of Chemistry and Chemical Biology Department, Cornell University will present Sirtuins and novel protein modifications in cell signaling and cancer
Tuesday, April 3rd 4:00 pm in CNS 333
Pizza and Drinks Provided
Sirtuins are known as nicotinamide adenine dinucleotide (NAD)-dependent deacetylases. They regulate aging, transcription, and metabolism, and are considered important targets for treating several human diseases. There are seven sirtuins in humans, SIRT1-7. Four of them (SIRT4-7) have very weak deacetylase activity, which have caused many confusions and debates in the biological community. My laboratory has recently discovered several novel enzymatic activities, such as desuccinylation and defatty-acylation, for several sirtuins with no robust deacetylase activity. This have led to the identification of previously unknown protein posttranslational modifications (PTMs) and revealed new regulatory mechanisms of biology. Furthermore, this finding has enabled us to develop compounds that can inhibit particular sirtuins selectively. Some of the selective sirtuins inhibitors can kill cancer cells in cell culture and inhibit tumor formation in mouse models at least partly via the regulation of c-Myc and Ras. The roles of sirtuins and the new PTMs in cancer are being elucidated.
Individuals with disabilities requiring accommodations should contact Paula Larsen at plarsen@ithaca.edu or (607) 274-3238. We ask that requests for accommodations be made as soon as possible.
https://www.ithaca.edu/intercom/article.php/20180330140730961