Ithaca College

Diethyl 4-(biphenyl-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 
Acta Cryst. (2014), (E70), o791, Steiger, Monacelli, Li, Hunting and Natale.

The crystal structure of diethyl 4-(biphenyl-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate was solved using Ithaca College’s single crystal X-ray diffractometer. The compound was synthesized by our collaborators at the University of Montana.

1,4-dihydropyridines (DHPs) are an extensively studied class of compounds that are known predominantly for their L-type gated calcium channel modulation. There have been extensive structure-activity relationship (SAR) studies done on DHPs that have revealed the basic structural requirements for robust binding affinity to calcium channels. Other studies in the field have shown DHPs bind to multiple receptors, most notably the multiple drug resistant protein 1 (MDR1).