Ithaca College

 Maksim Royzen of University at Albany will present

“Drug Delivery Using Bio-orthogonal Chemistry”

Tuesday, February 6th 4:10 pm in CNS 333

 The field of bio-orthogonal chemistry involves a special type of chemical reactions that can be done inside of living organisms. These reactions can be done under physiological conditions. The chemical reagents do not react with cellular components, such as DNA, RNA, proteins, sugars and others. Lastly, the chemical reagents and the reaction products do not interfere with native cellular metabolism. A bio-orthogonal reaction between trans-cyclooctene and tetrazine will be described in my presentation. In particular, this chemistry will be employed to concentrate and activate small molecule pro-drugs at a location of choice. The bio-orthogonal strategy involves a biomaterial that is strategically implanted and can react with systemically administered pro-drugs converting them into active cytotoxic agents leading to clear therapeutic benefits. The benefits of the localized pro-drug activation via a ‘catch and release’ strategy will be illustrated using xenograft tumors derived from human fibrosarcoma (HT1080), an aggressive cell line commonly used to evaluate new treatments for soft tissue sarcoma.

Individuals with disabilities requiring accommodations should contact Paula Larsen at plarsen@ithaca.edu or (607) 274-3238. We ask that requests for accommodations be made as soon as possible.